Munhu CYP2C19 Gene Polymorphism

CYP2C19 ndeimwe yemishonga yakakosha metabolizing enzymes mumhuri yeCYP450.Mazhinji endogenous substrates uye angangoita 2% yemishonga yekiriniki inogadziriswa neCYP2C19, senge metabolism ye antiplatelet aggregation inhibitors (senge clopidogrel), proton pump inhibitors (omeprazole), anticonvulsants, nezvimwewo. zvinodhaka zvinoenderana.Aya mapoinzi ekuchinja kwe * 2 (rs4244285) uye * 3 (rs4986893) anokonzera kurasikirwa kweiyo enzyme yakavharidzirwa neCYP2C19 gene uye kushaya simba kwe metabolic substrate kugona, uye kuwedzera kuwanda kweropa, kuitira kuti ikonzere kukanganisa kwezvinodhaka zvine chekuita ne kuwedzera kweropa.* 17 (rs12248560) inogona kuwedzera basa re enzyme rakavharidzirwa neCYP2C19 gene, kugadzirwa kwematabolites anoshanda, uye kuwedzera platelet aggregation inhibition uye kuwedzera njodzi yekubuda ropa.Kune vanhu vanononoka metabolism yezvinodhaka, kutora madosi akajairwa kwenguva yakareba kunokonzeresa muchetura uye mhedzisiro: kunyanya kukuvara kwechiropa, hematopoietic system kukuvara, kukuvara kwepakati tsinga, nezvimwewo, izvo zvinogona kutungamira kurufu mumatambudziko akaomarara.Zvinoenderana nekusiyana kwega kwega mune inofananidzwa yemetabolism yezvinodhaka, inowanzo kupatsanurwa kuita ina phenotypes, zvinoti ultra-fast metabolism (UM, * 17 / * 17, * 1 / * 17), kukurumidza metabolism (RM, * 1 / * 1). ), metabolism yepakati (IM, *1/*2, *1/*3), inononoka metabolism (PM, *2/*2, *2/*3, *3/*3).