Munhu CYP2C9 uye VKORC1 Gene Polymorphism
Product name
HWTS-GE014A-Human CYP2C9 uye VKORC1 Gene Polymorphism Detection Kit (Fluorescence PCR)
Chitupa
CE
Epidemiology
Warfarin ndeyemumuromo anticoagulant inowanzoshandiswa mukiriniki yekudzidzira parizvino, iyo inonyanya kuitirwa kudzivirira uye kurapwa kwezvirwere zvethromboembolic.Nekudaro, warfarin ine hwindo rekurapa shoma uye inosiyana zvakanyanya pakati pemarudzi akasiyana uye vanhu.Nhamba dzakaratidza kuti mutsauko wedosi yakagadzikana muvanhu vakasiyana inogona kudarika nguva dze20.Kubuda ropa kwakashata kunoitika mu15.2% yevarwere vanotora warfarin gore rega rega, iyo 3.5% yavo inobuda ropa rinouraya.Pharmacogenomic zvidzidzo zvakaratidza kuti genetic polymorphism yechinangwa enzyme VKORC1 uye metabolic enzyme CYP2C9 yewarfarin chinhu chakakosha chinokanganisa mutsauko wedosi yewarfarin.Warfarin inhibitor chaiyo yevhitamini K epoxide reductase (VKORC1), uye nokudaro inhibits clotting factor synthesis inosanganisira vitamin K uye inopa anticoagulation.Nhamba huru yezvidzidzo zvakaratidza kuti gene polymorphism yeVKORC1 mutsigiri ndiyo inonyanya kukosha inokanganisa nhangemutange uye misiyano yemunhu muyero inodiwa yewarfarin.Warfarin inogadziriswa neCYP2C9, uye inochinja inononoka metabolism ye warfarin.Vanhu vanoshandisa warfarin vane njodzi huru (yakapetwa kaviri kusvika katatu kumusoro) yekubuda ropa padanho rekutanga rekushandisa.
Channel
| FAM | VKORC1 (-1639G>A) |
| CY5 | CYP2C9*3 |
| VIC/HEX | IC |
Technical Parameters
| Storage | Mvura: ≤-18℃ |
| Sherufu-hupenyu | 12 mwedzi |
| Type Type | Fresh EDTA anticoagulated ropa |
| CV | ≤5.0% |
| LoD | 1.0ng/μL |
| Zvakananga | Iko hakuna kuyambuka-reactivity pamwe nekumwe kunoenderana kutevedzana kwegenome yemunhu (yemunhu CYP2C19 gene, yemunhu RPN2 gene);shanduko yeCYP2C9*13 uye VKORC1 (3730G>A) kunze kwekuonekwa kwetiti iyi. |
| Zvishandiso Zvishandiso | Applied Biosystems 7500 Chaiyo-Nguva PCR Systems Applied Biosystems 7500 Fast Real-Time PCR Systems QuantStudio®5 Chaiyo-Nguva PCR Systems SLAN-96P Chaiyo-Nguva PCR Systems LightCycler®480 Chaiyo-Nguva PCR system LineGene 9600 Plus Chaiyo-Nguva PCR Detection System MA-6000 Chaiyo-Nguva Quantitative Thermal Cycler BioRad CFX96 Chaiyo-Nguva PCR System BioRad CFX Opus 96 Chaiyo-Nguva PCR System |
Kuyerera Kwebasa
Inokurudzirwa kubvisa reagent: Macro & Micro-Test Viral DNA/RNA Kit(HWTS-3001, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) uye Macro & Micro-Test Automatic Nucleic Acid Extractor(HWTS- 3006).
