Human Cytomegalovirus (HCMV) Nucleic Acid

Human cytomegalovirus (HCMV) inhengo ine genome yakakura kwazvo mumhuri yeherpes virus uye inogona kukodha anopfuura mazana maviri mapuroteni.HCMV yakaganhurirwa padiki padanho rayo revanhu, uye hapasati pave nemhando yemhuka yehutachiona hwayo.HCMV ine inononoka uye yakareba kudzokorora kutenderera kuumba intranuclear inclusion body, uye kukonzeresa kugadzirwa kweperinuclear uye cytoplasmic inclusion miviri uye sero kuzvimba (giant masero), nokudaro zita.Maererano nehterogeneity ye genome yayo uye phenotype, HCMV inogona kugoverwa mumhando dzakasiyana-siyana, pakati payo pane mamwe maantigenic akasiyana, ayo, zvisinei, haana kukosha kwekliniki.

Utachiona hweHCMV chirwere chehurongwa, icho chinosanganisa nhengo dzakawanda, chine zviratidzo zvakaoma uye zvakasiyana, kazhinji chinyararire, uye chinogona kuita kuti varwere vashoma vatange maronda akawanda-organ zvinosanganisira retinitis, hepatitis, pneumonia, encephalitis, colitis, monocytosis, uye thrombocytopenic. purpura.Hutachiona hweHCMV hwakanyanya uye hunoratidzika kunge hwakapararira pasi rese.Inonyanya kuwanda muhuwandu hwevanhu, nehuwandu hwehuwandu hwe45-50% uye kupfuura 90% munyika dzakabudirira uye dzichiri kusimukira, maererano.HCMV inogona kurara mumuviri kwenguva yakareba.Kana kusadzivirirwa kwemuviri kwapera simba, hutachiona huchaitwa kuti hukonzere zvirwere, kunyanya hutachiona hweleukemia nevarwere vanoisirwa, uye hunogona kukonzera kuisirwa nhengo necrosis uye kuisa hupenyu hwevarwere munjodzi.Pamusoro pekuzvara mwana akafa, kupfupfudzika uye kusununguka nguva isati yakwana kuburikidza nehutachiona hwe intrauterine, cytomegalovirus inogonawo kukonzera kukanganisa kwekuzvarwa, saka hutachiona hweHCMV hunokwanisa kukanganisa hutano hwepamberi uye mushure mekusununguka uye hutano hwevanhu.