Mycobacterium Tuberculosis INH Resistance

Tsanangudzo Pfupi:

Iyi kit inoshandiswa kuona zvakanaka gene mutation ye315th amino acid yekatG gene (K315G> C) uye gene mutation yedunhu rinokurudzira reInhA gene (- 15 C> T).

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Product Detail

Product Tags

Product Name

HWTS-RT002A-Mycobacterium Tuberculosis Isoniazid Resistance Detection Kit (Fluorescence PCR)

Epidemiology

Isoniazid, mushonga unokosha wekurwisa tibhii wakaunzwa muna 1952, mumwe wemishonga inoshanda pakurapa kwakabatanidzwa kwechirwere cherurindi uye mushonga mumwechete wechirwere cherurindi.

KatG ndiyo huru gene encoding catalase-peroxidase uye katG gene mutation inogona kusimudzira synthesis ye mycolic acid cell wall, ichiita kuti utachiona husarambe kune isoniazid.KatG kutaura kwakashata kwakabatana nekuchinja kweINH-MIC, uye kuderera kwe2-katG kutaura kunoguma nekuwedzera zvishoma kwe2-fold muMIC.Chimwe chikonzero chekusagadzikana kwe isoniazid mu mycobacterium tuberculosis inoitika apo kuiswa kwebhesi, kudzima kana kuchinja kunoitika muInhA gene locus ye mycobacterium tuberculosis.

Channel

ROX	inhA (-15C>T) site·
CY5	katG (315G>C) saiti
VIC (HEX)	IS6110

Technical Parameters

Storage	≤-18℃ Murima
Sherufu-hupenyu	12 mwedzi
Type Type	Sputum
CV	≤5.0%
LoD	1 × 10³utachiona/mL
Zvakananga	No-cross reactivity pamwe nekuchinja kwenzvimbo ina dzekuramba zvinodhaka (511, 516, 526 uye 531) ye rpoB gene kunze kwekuonekwa kwechikwata chekutsvaga. Zvishandiso Zvinoshanda: Applied Biosystems 7500 Chaiyo-Nguva PCR Systems Applied Biosystems 7500 Fast Real-Time PCR Systems QuantStudio®5 Chaiyo-Nguva PCR Systems SLAN-96P Chaiyo-Nguva PCR Systems LightCycler®480 Chaiyo-Nguva PCR system LineGene 9600 Plus Chaiyo-Nguva PCR Detection System MA-6000 Chaiyo-Nguva Quantitative Thermal Cycler BioRad CFX96 Chaiyo-Nguva PCR System BioRad CFX Opus 96 Chaiyo-Nguva PCR System